In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy.
نویسندگان
چکیده
Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii. In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.
منابع مشابه
In Vitro Interactions of Antibiotic Combinations of Colistin, Tigecycline, and Doripenem Against Extensively Drug-Resistant and Multidrug-Resistant Acinetobacter baumannii
BACKGROUND Acinetobacter baumannii infections are difficult to treat owing to the emergence of various antibiotic resistant isolates. Because treatment options are limited for multidrug-resistant (MDR) A. baumannii infection, the discovery of new therapies, including combination therapy, is required. We evaluated the synergistic activity of colistin, doripenem, and tigecycline combinations agai...
متن کاملSynergy testing by Etest, microdilution checkerboard, and time-kill methods for pan-drug-resistant Acinetobacter baumannii.
Pan-drug-resistant (PDR) Acinetobacter baumannii is an important nosocomial pathogen that poses therapeutic challenges. Tigecycline alone or in combination with agents such as colestimethate, imipenem, and/or amikacin is being used clinically to treat PDR A. baumannii infections. The purpose of this study was to compare in vitro susceptibility testing by epsilometric (Etest) methods and the che...
متن کاملIn vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii.
This survey was conducted to evaluate the in vitro activity of tigecycline against 50 isolates of multidrug-resistant (MDR) Acinetobacter baumannii. Isolates of A. baumannii were resistant to ciprofloxacin, chloramphenicol, imipenem, levofloxacin, piperacillin and piperacillin-tazobactam, but were always susceptible to colistin. MICs of tigecycline were determined by E-test in Mueller-Hinton ag...
متن کاملPrevalence of tigecycline resistant multidrug resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex from a tertiary care hospital in Nepal
Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex is an important nosocomial pathogen. Rapid development of resistance to multiple drugs limits the therapeutic options for the treatment of infections by ACB complex. The current study aimed to find the prevalence of ACB complex and know the antibiogram of these clinical isolates including the rate of multidrug resistance (MDR) an...
متن کاملSensitivity of levofloxacin in combination with ampicillin-sulbactam and tigecycline against multidrug-resistant Acinetobacter baumannii
BACKGROUND AND OBJECTIVES The selection of alternative treatment options with antibiotic combinations may be used for successful managing of multidrug-resistant Acinetobacter baumannii. The aim of this study was to determine the synergistic effects of ampicillin-sulbactam combined with either levofloxacin or tigecycline against MDR A. baumannii. MATERIALS AND METHODS A total 124 of A.baumanni...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 52 8 شماره
صفحات -
تاریخ انتشار 2008